Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections.
- Author(s): Shehata, Hesham M;
- Murphy, Andrew J;
- Lee, Man Kit Sam;
- Gardiner, Clair M;
- Crowe, Suzanne M;
- Sanjabi, Shomyseh;
- Finlay, David K;
- Palmer, Clovis Steve
- et al.
Published Web Locationhttps://www.frontiersin.org/articles/10.3389/fimmu.2017.01311/full
The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty-acid oxidation (sugar or fat) regulates the capacity of immune cells to mount robust and effective immune responses. We will also discuss how fine-tuning sugar and fat metabolism may be exploited as a novel immunotherapeutic strategy to fight viral infections or improve vaccine efficacy.