Limits of Ligand Selectivity from Docking to Models: In Silico Screening for A1 Adenosine Receptor Antagonists
- Author(s): Sali, Andrej
- Kolb, P
- Phan, K
- Gao, ZG
- Marko, AC
- Jacobson, KA
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3503826?pdf=render
G protein-coupled receptors (GPCRs) are attractive targets for pharmaceutical research. With the recent determination of several GPCR X-ray structures, the applicability of structure-based computational methods for ligand identification, such as docking, h
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