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Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates
- Shen, Xiaoying;
- Duffy, Ryan;
- Howington, Robert;
- Cope, Alethea;
- Sadagopal, Shanmugalakshmi;
- Park, Haesun;
- Pal, Ranajit;
- Kwa, Suefen;
- Ding, Song;
- Yang, Otto O;
- Fouda, Genevieve G;
- Le Grand, Roger;
- Bolton, Diane;
- Esteban, Mariano;
- Phogat, Sanjay;
- Roederer, Mario;
- Amara, Rama R;
- Picker, Louis J;
- Seder, Robert A;
- McElrath, M Juliana;
- Barnett, Susan;
- Permar, Sallie R;
- Shattock, Robin;
- DeVico, Anthony L;
- Felber, Barbara K;
- Pavlakis, George N;
- Pantaleo, Giuseppe;
- Korber, Bette T;
- Montefiori, David C;
- Tomaras, Georgia D
- Editor(s): Kirchhoff, F
- et al.
Published Web Location
https://doi.org/10.1128/jvi.03635-14Abstract
To evaluate antibody specificities induced by simian immunodeficiency virus (SIV) versus human immunodeficiency virus type 1 (HIV-1) envelope antigens in nonhuman primate (NHP), we profiled binding antibody responses to linear epitopes in NHP studies with HIV-1 or SIV immunogens. We found that, overall, HIV-1 Env IgG responses were dominated by V3, with the notable exception of the responses to the vaccine strain A244 Env that were dominated by V2, whereas the anti-SIVmac239 Env responses were dominated by V2 regardless of the vaccine regimen.
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