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Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids.

  • Author(s): Jin, Haibao
  • Ding, Yan-Huai
  • Wang, Mingming
  • Song, Yang
  • Liao, Zhihao
  • Newcomb, Christina J
  • Wu, Xuepeng
  • Tang, Xian-Qiong
  • Li, Zheng
  • Lin, Yuehe
  • Yan, Feng
  • Jian, Tengyue
  • Mu, Peng
  • Chen, Chun-Long
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pubmed/?term=29348551
No data is associated with this publication.
Abstract

Despite recent advances in the assembly of organic nanotubes, conferral of sequence-defined engineering and dynamic response characteristics to the tubules remains a challenge. Here we report a new family of highly designable and dynamic nanotubes assembled from sequence-defined peptoids through a unique "rolling-up and closure of nanosheet" mechanism. During the assembly process, amorphous spherical particles of amphiphilic peptoid oligomers crystallize to form well-defined nanosheets before folding to form single-walled nanotubes. These nanotubes undergo a pH-triggered, reversible contraction-expansion motion. By varying the number of hydrophobic residues of peptoids, we demonstrate tuning of nanotube wall thickness, diameter, and mechanical properties. Atomic force microscopy-based mechanical measurements show peptoid nanotubes are highly stiff (Young's Modulus ~13-17 GPa). We further demonstrate the precise incorporation of functional groups within nanotubes and their applications in water decontamination and cellular adhesion and uptake. These nanotubes provide a robust platform for developing biomimetic materials tailored to specific applications.

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