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Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China.

  • Author(s): Wu, Aiping;
  • Peng, Yousong;
  • Huang, Baoying;
  • Ding, Xiao;
  • Wang, Xianyue;
  • Niu, Peihua;
  • Meng, Jing;
  • Zhu, Zhaozhong;
  • Zhang, Zheng;
  • Wang, Jiangyuan;
  • Sheng, Jie;
  • Quan, Lijun;
  • Xia, Zanxian;
  • Tan, Wenjie;
  • Cheng, Genhong;
  • Jiang, Taijiao
  • et al.
Abstract

An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV.

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