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Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles.

  • Author(s): Fang, Ronnie H
  • Hu, Che-Ming J
  • Chen, Kevin NH
  • Luk, Brian T
  • Carpenter, Cody W
  • Gao, Weiwei
  • Li, Shulin
  • Zhang, Dong-Er
  • Lu, Weiyue
  • Zhang, Liangfang
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831007/
No data is associated with this publication.
Abstract

RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.

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