Complexities of TGF-β targeted cancer therapy.
- Author(s): Akhurst, Rosemary
- Connolly, EC
- Freimuth, J
- Akhurst, RJ
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3399319?pdf=render
Many advanced tumors produce excessive amounts of Transforming Growth Factor-β (TGF-β) which, in normal epithelial cells, is a potent growth inhibitor. However, in oncogenically activated cells, the homeostatic action of TGF-β is often diverted along alter