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Concise Review: Human Pluripotent Stem Cells to Produce Cell-Based Cancer Immunotherapy.

  • Author(s): Zhu, Huang
  • Lai, Yi-Shin
  • Li, Ye
  • Blum, Robert H
  • Kaufman, Dan S
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914526/
No data is associated with this publication.
Abstract

Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These PSC-derived lymphocytes have phenotype and function similar to primary lymphocytes isolated from peripheral blood. PSC-derived T and NK cells have advantages compared with primary immune cells, as they can be precisely engineered to introduce improved anti-tumor activity and produced in essentially unlimited numbers. Stem Cells 2018;36:134-145.

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