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Open Access Publications from the University of California

Crystalline folliculitis revealed by non-aqueous staining technique

  • Author(s): Siscos, Spyros Michael
  • Tran, Chi
  • Fischer, Ryan
  • Fraga, Garth
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license

Necrotizing infundibular crystalline folliculitis (NICF) is a rare superficial folliculitis characterized by expansive deposits of birefringent crystallized lipid. We report a case of NICF in a transplant patient presenting with folliculocentric acneiform papules across the lateral face and neck. Biopsy demonstrated intrafollicular crystalline deposits within an intact epidermis. Diagnostic crystals were identified using a non-aqueous histologic technique involving thick unstained sections. To our knowledge, this is the first report of NICF in a transplant patient. Our case suggests NICF is a follicular disorder and highlights a technique that may prevent loss of birefringent crystals and assist in facilitating accurate diagnosis.

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