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Open Access Publications from the University of California

Neonatal seizures and therapeutic hypothermia for hypoxic-ischemic encephalopathy.

  • Author(s): Gano, Dawn
  • Orbach, Sharon A
  • Bonifacio, Sonia L
  • Glass, Hannah C
  • et al.

Published Web Location

Neonatal seizures are associated with morbidity and mortality. Hypoxic-ischemic encephalopathy (HIE) is the most common cause of seizures in newborns. Neonatal animal models suggest that therapeutic hypothermia can reduce seizures and epileptiform activity in the setting of hypoxia-ischemia, however data from human studies have conflicting results. In this research highlight, we will discuss the findings of our recent study that demonstrated a decreased seizure burden in term newborns with moderate HIE treated with hypothermia.

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