Neonatal seizures and therapeutic hypothermia for hypoxic-ischemic encephalopathy.
- Author(s): Gano, Dawn
- Orbach, Sharon A
- Bonifacio, Sonia L
- Glass, Hannah C
- et al.
Published Web Locationhttps://doi.org/10.14800/mce.88
Neonatal seizures are associated with morbidity and mortality. Hypoxic-ischemic encephalopathy (HIE) is the most common cause of seizures in newborns. Neonatal animal models suggest that therapeutic hypothermia can reduce seizures and epileptiform activity in the setting of hypoxia-ischemia, however data from human studies have conflicting results. In this research highlight, we will discuss the findings of our recent study that demonstrated a decreased seizure burden in term newborns with moderate HIE treated with hypothermia.