Skip to main content
eScholarship
Open Access Publications from the University of California
Refine Search

UC San Diego

UC San Diego Previously Published Works bannerUC San Diego

EnABLing microprocessor for apoptosis

Published Web Location

https://doi.org/10.1080/23723556.2015.1081860
Abstract

The Microprocessor complex consisting of DROSHA (a type III ribonuclease) and DGCR8 (DiGeorge syndrome critical region gene 8-encoded RNA binding protein) recognizes and cleaves the precursor microRNA hairpin (pre-miRNA) from the primary microRNA transcript (pri-miRNA). The Abelson tyrosine kinase 1 (ABL) phosphorylates DGCR8 to stimulate the cleavage of a subset of pro-apoptotic pri-miRNAs, thus expanding the nuclear functions of ABL to include regulation of RNA processing.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.


Top