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Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
- Ritter, McKenzie L;
- Guo, Wei;
- Samuels, Jack F;
- Wang, Ying;
- Nestadt, Paul S;
- Krasnow, Janice;
- Greenberg, Benjamin D;
- Fyer, Abby J;
- McCracken, James T;
- Geller, Daniel A;
- Murphy, Dennis L;
- Knowles, James A;
- Grados, Marco A;
- Riddle, Mark A;
- Rasmussen, Steven A;
- McLaughlin, Nicole C;
- Nurmi, Erika L;
- Askland, Kathleen D;
- Cullen, Bernadette;
- Piacentini, John;
- Pauls, David L;
- Bienvenu, Joseph;
- Stewart, Evelyn;
- Goes, Fernando S;
- Maher, Brion;
- Pulver, Ann E;
- Mattheisen, Manuel;
- Qian, Ji;
- Nestadt, Gerald;
- Shugart, Yin Yao
- et al.
Published Web Location
https://doi.org/10.3389/fnmol.2017.00083Abstract
Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders. Methods: A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; p-values for the protein-protein interaction analysis was calculated using permutation. Conclusion: None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.
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