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Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD).

  • Author(s): Ritter, McKenzie L
  • Guo, Wei
  • Samuels, Jack F
  • Wang, Ying
  • Nestadt, Paul S
  • Krasnow, Janice
  • Greenberg, Benjamin D
  • Fyer, Abby J
  • McCracken, James T
  • Geller, Daniel A
  • Murphy, Dennis L
  • Knowles, James A
  • Grados, Marco A
  • Riddle, Mark A
  • Rasmussen, Steven A
  • McLaughlin, Nicole C
  • Nurmi, Erika L
  • Askland, Kathleen D
  • Cullen, Bernadette
  • Piacentini, John
  • Pauls, David L
  • Bienvenu, Joseph
  • Stewart, Evelyn
  • Goes, Fernando S
  • Maher, Brion
  • Pulver, Ann E
  • Mattheisen, Manuel
  • Qian, Ji
  • Nestadt, Gerald
  • Shugart, Yin Yao
  • et al.
Abstract

Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders. Methods: A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; p-values for the protein-protein interaction analysis was calculated using permutation. Conclusion: None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.

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