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Open Access Publications from the University of California

Multicentric giant cell tumor: report of five new cases.

  • Author(s): Hindman, BW
  • Seeger, LL
  • Stanley, P
  • Forrester, DM
  • Schwinn, CP
  • Tan, SZ
  • et al.

The typical giant cell tumor (GCT) is a solitary neoplams that occurs in the epiphysis or epimetaphysis of long bones. GCT is seen with a slightly increased frequency in females, and 70% of patients are between 20 and 40 years of age at the time of presentation. Multicentric giant cell tumor (MGCT; two or more centers) is an unusual variant of GCT. Patients with MGCT are likely to be younger than those with a solitary lesion. The multicentric variety is often of a higher stage at diagnosis and is more often associated with a pathological fracture than the unifocal tumor. We are reporting five new cases of MGCT, with a total of 21 tumors seen over a period of 25 years from 1967 to 1992.

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