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High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser.

  • Author(s): Wang, Pu
  • Ma, Teng
  • Slipchenko, Mikhail N
  • Liang, Shanshan
  • Hui, Jie
  • Shung, K Kirk
  • Roy, Sukesh
  • Sturek, Michael
  • Zhou, Qifa
  • Chen, Zhongping
  • Cheng, Ji-Xin
  • et al.

Published Web Location

https://doi.org/10.1038/srep06889Creative Commons 'BY' version 4.0 license
Abstract

Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (~50 s per frame) due to the lack of a suitable laser source for high-speed excitation of molecular overtone vibrations. Here, we report an improvement in IVPA imaging speed by two orders of magnitude, to 1.0 s per frame, enabled by a custom-built, 2-kHz master oscillator power amplifier (MOPA)-pumped, barium nitrite [Ba(NO3)2] Raman laser. This advancement narrows the gap in translating the IVPA technology to the clinical setting.

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