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High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz Barium Nitrite Raman Laser

  • Author(s): Wang, P
  • Ma, T
  • Slipchenko, MN
  • Liang, S
  • Hui, J
  • Shung, KK
  • Roy, S
  • Sturek, M
  • Zhou, Q
  • Chen, Z
  • Cheng, JX
  • et al.

Published Web Location

https://doi.org/10.1038/srep06889Creative Commons Attribution 4.0 International Public License
Abstract

Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (∼50 s per frame) due to the lack of a suitable laser source for high-speed excitation of molecular overtone vibrations. Here, we report an improvement in IVPA imaging speed by two orders of magnitude, to 1.0 s per frame, enabled by a custom-built, 2-kHz master oscillator power amplifier (MOPA)-pumped, barium nitrite [Ba(NO3)2] Raman laser. This advancement narrows the gap in translating the IVPA technology to the clinical setting.

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