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Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.
Published Web Location
http://europepmc.org/articles/PMC3920566?pdf=renderNo data is associated with this publication.
Abstract
Type I interferons (IFN-1s) are antiviral cytokines that suppress blood production while paradoxically inducing hematopoietic stem cell (HSC) proliferation. Here, we clarify the relationship between the proliferative and suppressive effects of IFN-1s on HS
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