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Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.

  • Author(s): Passegue, Emmanuelle
  • Pietras, EM
  • Lakshminarasimhan, R
  • Techner, J-M
  • Fong, S
  • Flach, J
  • Binnewies, M
  • Passegué, E
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3920566?pdf=render
No data is associated with this publication.
Abstract

Type I interferons (IFN-1s) are antiviral cytokines that suppress blood production while paradoxically inducing hematopoietic stem cell (HSC) proliferation. Here, we clarify the relationship between the proliferative and suppressive effects of IFN-1s on HS

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