Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.
- Author(s): Passegue, Emmanuelle
- Pietras, EM
- Lakshminarasimhan, R
- Techner, J-M
- Fong, S
- Flach, J
- Binnewies, M
- Passegué, E
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3920566?pdf=render
Type I interferons (IFN-1s) are antiviral cytokines that suppress blood production while paradoxically inducing hematopoietic stem cell (HSC) proliferation. Here, we clarify the relationship between the proliferative and suppressive effects of IFN-1s on HS