Phylo-VISTA: An Interactive Visualization Tool for Multiple DNA Sequence Alignments
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Phylo-VISTA: An Interactive Visualization Tool for Multiple DNA Sequence Alignments

  • Author(s): Shah, Nameeta;
  • Couronne, Olivier;
  • Pennacchio, Len A.;
  • Brudno, Michael;
  • Batzoglou, Serafim;
  • Bethel, E. Wes;
  • Rubin, Edward M.;
  • Hamann, Bernd;
  • Dubchak, Inna
  • et al.
Abstract

We have developed Phylo-VISTA (Shah et al., 2003), an interactive software tool for analyzing multiple alignments by visualizing a similarity measure for DNA sequences of multiple species. The complexity of visual presentation is effectively organized using a framework based upon inter-species phylogenetic relationships. The phylogenetic organization supports rapid, user-guided inter-species comparison. To aid in navigation through large sequence datasets, Phylo-VISTA provides a user with the ability to select and view data at varying resolutions. The combination of multi-resolution data visualization and analysis, combined with the phylogenetic framework for inter-species comparison, produces a highly flexible and powerful tool for visual data analysis of multiple sequence alignments.

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