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YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations.

  • Author(s): Lyubasyuk, Vera;
  • Ouyang, Hong;
  • Yu, Fa-Xing;
  • Guan, Kun-Liang;
  • Zhang, Kang
  • et al.
Abstract

Uveal melanoma (UM) is the most common adult intraocular tumor. UM often involves activating mutations in guanine nucleotide binding protein (G protein), q polypeptide (GQ), or G Protein, α 11 (G11). We show that the Yes-associated protein (Yap) inhibitor verteporfin blocks tumor growth of Gq/11-mutated UM cells.

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