UC San Diego
YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations.
- Author(s): Lyubasyuk, V
- Ouyang, H
- Yu, F-X
- Guan, K-L
- Zhang, K
- et al.
Published Web Locationhttps://doi.org/10.4161/23723548.2014.970957
Uveal melanoma (UM) is the most common adult intraocular tumor. UM often involves activating mutations in guanine nucleotide binding protein (G protein), q polypeptide (GQ), or G Protein, α 11 (G11). We show that the Yes-associated protein (Yap) inhibitor verteporfin blocks tumor growth of Gq/11-mutated UM cells.
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