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Nitric oxide releasing materials triggered by near-infrared excitation through tissue filters

  • Author(s): Burks, PT
  • Garcia, JV
  • Gonzalezirias, R
  • Tillman, JT
  • Niu, M
  • Mikhailovsky, AA
  • Zhang, J
  • Zhang, F
  • Ford, PC
  • et al.

Published Web Location

https://doi.org/10.1021/ja408516w
Abstract

Novel materials for the phototherapeutic release of the bioregulator nitric oxide (nitrogen monoxide) are described. Also reported is a method for scanning these materials with a focused NIR beam to induce photouncaging while minimizing damage from local heating. The new materials consist of poly(dimethylsiloxane) composites with near-infrared-to-visible upconverting nanoparticles (UCNPs) that are cast into a biocompatible polymer disk (PD). These PDs are then impregnated with the photochemical nitric oxide precursor Roussin's black salt (RBS) to give UCNP-RBS-PD devices that generate NO when irradiated with 980 nm light. When the UCNP-RBS-PD composites were irradiated with NIR light through filters composed of porcine tissue, physiologically relevant NO concentrations were released, thus demonstrating the potential of such devices for minimally invasive phototherapeutic applications. © 2013 American Chemical Society.

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