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BAK and NOXA Are Critical Determinants of Mitochondrial Apoptosis Induced by Bortezomib in Mesothelioma

  • Author(s): Broaddus, V Courtney
  • Busacca, S
  • Chacko, AD
  • Klabatsa, A
  • Arthur, K
  • Sheaff, M
  • Gunasekharan, VK
  • Gorski, JJ
  • El-Tanani, M
  • Broaddus, VC
  • Gaudino, G
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3676324?pdf=render
No data is associated with this publication.
Abstract

Based on promising preclinical efficacy associated with the 20S proteasome inhibitor bortezomib in malignant pleural mesothelioma (MPM), two phase II clinical trials have been initiated (EORTC 08052 and ICORG 05-10). However, the potential mechanisms under

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