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BAK and NOXA Are Critical Determinants of Mitochondrial Apoptosis Induced by Bortezomib in Mesothelioma

  • Author(s): Broaddus, V Courtney;
  • Busacca, S;
  • Chacko, AD;
  • Klabatsa, A;
  • Arthur, K;
  • Sheaff, M;
  • Gunasekharan, VK;
  • Gorski, JJ;
  • El-Tanani, M;
  • Broaddus, VC;
  • Gaudino, G
  • et al.

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Based on promising preclinical efficacy associated with the 20S proteasome inhibitor bortezomib in malignant pleural mesothelioma (MPM), two phase II clinical trials have been initiated (EORTC 08052 and ICORG 05-10). However, the potential mechanisms under

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