Skip to main content
eScholarship
Open Access Publications from the University of California

DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers

  • Author(s): Lee, W
  • Ray, R
  • Bergen, AW
  • Swan, GE
  • Thomas, P
  • Tyndale, RF
  • Benowitz, NL
  • Lerman, C
  • Conti, DV
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376177/pdf/nihms370286.pdf
No data is associated with this publication.
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License
Abstract

Nicotine metabolism and genetic variation have an impact on nicotine addiction and smoking abstinence; however, further research is required. The nicotine metabolite ratio (NMR) is a robust biomarker of nicotine metabolism used to categorize slow and normal nicotine metabolizers (lower 25th quartile cut off). In two randomized clinical trials of smoking abstinence treatments, we conducted NMR-stratified analyses on smoking abstinence across 13 regions coding for nicotinic acetylcholine receptors and proteins involved in the dopamine reward system. Gene×NMR interaction P-values were adjusted for multiple correlated tests, and we used a Bonferroni-corrected α-level of 0.004 to determine system-wide significance. Three single-nucleotide polymorphisms in DRD1 (rs11746641, rs2168631, and rs11749035) had significant interactions (0.001≤adjusted P-values≤0.004) with increased odds of abstinence within slow metabolizers (odds ratios=3.1-3.5, 95% confidence interval 1.7-6.7). Our findings support the role of DRD1 in nicotine dependence, and identify genetic and nicotine metabolism profiles that may interact to impact nicotine dependence. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item