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Open Access Publications from the University of California

Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia

  • Author(s): Muschen, Markus
  • Sun, H
  • Lin, DC
  • Guo, X
  • Masouleh, BK
  • Gery, S
  • Cao, Q
  • Alkan, S
  • Ikezoe, T
  • Akiba, C
  • Paquette, R
  • et al.

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Survival of cancer cells relies on the unfolded protein response (UPR) to resist stress triggered by the accumulation of misfolded proteins within the endoplasmic reticulum (ER). The IRE1α-XBP1 pathway, a key branch of the UPR, is activated in many cancers

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