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Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia

  • Author(s): Muschen, Markus
  • Sun, H
  • Lin, DC
  • Guo, X
  • Masouleh, BK
  • Gery, S
  • Cao, Q
  • Alkan, S
  • Ikezoe, T
  • Akiba, C
  • Paquette, R
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4951325?pdf=render
No data is associated with this publication.
Abstract

Survival of cancer cells relies on the unfolded protein response (UPR) to resist stress triggered by the accumulation of misfolded proteins within the endoplasmic reticulum (ER). The IRE1α-XBP1 pathway, a key branch of the UPR, is activated in many cancers

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