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Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease

  • Author(s): Astarita, Giuseppe
  • Jung, Kwang-Mook
  • Vasilevko, Vitaly
  • DiPatrizio, Nicholas V.
  • Martin, Sarah K.
  • Cribbs, David H.
  • Head, Elizabeth
  • Cotman, Carl W.
  • Piomelli, Daniele
  • et al.
Creative Commons Attribution 4.0 International Public License
Abstract

The molecular bases of Alzheimer's disease (AD) remain unclear. We used a lipidomic approach to identify lipid abnormalities in the brains of subjects with AD (N = 37) compared to age-matched controls (N = 17). The analyses revealed statistically detectable elevations in levels of non-esterified monounsaturated fatty acids (MUFAs) and mead acid (20:3n-9) in mid-frontal cortex, temporal cortex and hippocampus of AD patients. Further studies showed that brain mRNAs encoding for isoforms of the rate-limiting enzyme in MUFAs biosynthesis, stearoyl-CoA desaturase (SCD-1, SCD-5a and SCD-5b), were elevated in subjects with AD. The monounsaturated/saturated fatty acid ratio (‘desaturation index’) – displayed a strong negative correlation with measures of cognition: the Mini Mental State Examination test (r = −0.80; P = 0.0001) and the Boston Naming test (r = −0.57; P = 0.0071). Our results reveal a previously unrecognized role for the lipogenic enzyme SCD in AD.

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