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Open Access Publications from the University of California

Pyruvate Kinase M2 Expression, but Not Pyruvate Kinase Activity, Is Up-Regulated in a Grade-Specific Manner in Human Glioma

  • Author(s): Ronen, Sabrina
  • Pieper, Russell
  • Phillips, Joanna
  • Wiencke, John
  • Mukherjee, J
  • Phillips, JJ
  • Zheng, S
  • Ronen, SM
  • Pieper, RO
  • et al.

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Normal tissues express the M1 isoform of pyruvate kinase (PK) that helps generate and funnel pyruvate into the mitochondria for ATP production. Tumors, in contrast, express the less active PKM2 isoform, which limits pyruvate production and spares glycolyti

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