UC Irvine

Mitochondrial function can be directly linked to protection from certain chronic diseases and conditions, such as heart disease, diabetes, metabolic syndrome and chronic inflammation, as well as the aging processes. Mitochondria are central to normal glucose, amino acid and fatty acid metabolism, in addition to antioxidant modulation and virtually all aspects of cell turnover and maintenance. Nutrition plays an essential role in optimizing such functions. We describe strategies for the regulation of mitochondria, as well as metabolic strategies for dealing with the thousands of compounds in plants and animal tissues that are metabolically important. Many of these compounds function to signal the up- or downregulation of mitochondria or act as antioxidants.