School of Medicine

The purpose of this study is to evaluate the relationship between pregnancy and meningioma progression, using the surrogate measure of hospital admission for meningioma resection. If progesterone plays a clinically significant role in the pathogenesis of meningioma, then exposure to high doses of progesterone during pregnancy may increase the growth of an existing, subclinical meningioma causing it to become symptomatic. To investigate whether such a pattern can be observed, we calculated the baseline rates of prior pregnancy in three different populations to better understand whether pregnancy was associated with meningioma resection. We report hazard ratios for recent pregnancy as a risk factor for these conditions.