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Open Access Publications from the University of California

ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC.

  • Author(s): Kapila, Yvonne
  • Kamarajan, P
  • Shin, JM
  • Qian, X
  • Matte, B
  • Zhu, JY
  • Kapila, YL
  • et al.

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CD44, an extracellular matrix (ECM) receptor, has been described as a cancer stem cell marker in multiple cancers, including head and neck squamous cell carcinoma (HNSCC). HNSCC orasphere formation or stemness was characterized by cleavage of CD44, and thu

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