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An AAA+ ATPase Clamshell Targets Transposition.
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https://doi.org/10.1016/j.cell.2015.07.050Abstract
DNA transposition plays key roles in genome diversity, pathogenesis, and evolution. Yet, structural and mechanistic information on transposition targeting and regulation is limited. Arias-Palomo and Berger now define the decameric organization of the AAA+ ATPase IstB, unveiling key insights into its targeting and regulation of IstA transposase activity.
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