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HMGB1 Accelerates Alveolar Epithelial Repair via an IL-1β- and αvβ6 Integrin-dependent Activation of TGF-β1

  • Author(s): Matthay, Michael
  • Pittet, JF
  • Koh, H
  • Fang, X
  • Iles, K
  • Christiaans, S
  • Anjun, N
  • Wagener, BM
  • Park, DW
  • Zmijewski, JW
  • Matthay, MA
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3655948?pdf=render
No data is associated with this publication.
Abstract

High mobility group box 1 (HMGB1) protein is a danger-signaling molecule, known to activate an inflammatory response via TLR4 and RAGE. HMGB1 can be either actively secreted or passively released from damaged alveolar epithelial cells. Previous studies hav

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