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diCal-IBD: demography-aware inference of identity-by-descent tracts in unrelated individuals

Published Web Location

https://doi.org/10.1093/bioinformatics/btu563
Abstract

Unlabelled

We present a tool, diCal-IBD, for detecting identity-by-descent (IBD) tracts between pairs of genomic sequences. Our method builds on a recent demographic inference method based on the coalescent with recombination, and is able to incorporate demographic information as a prior. Simulation study shows that diCal-IBD has significantly higher recall and precision than that of existing single-nucleotide polymorphism-based IBD detection methods, while retaining reasonable accuracy for IBD tracts as small as 0.1 cM.

Availability

http://sourceforge.net/projects/dical-ibd.

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