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Pathogenic CD4+ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes

  • Author(s): Anderson, Mark
  • Mohan, JF
  • Calderon, B
  • Anderson, MS
  • Unanue, ER
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3804950?pdf=render
No data is associated with this publication.
Abstract

In the nonobese diabetic mouse, a predominant component of the autoreactive CD4+ T cell repertoire is directed against the B:9-23 segment of the insulin B chain. Previous studies established that the majority of insulin-reactive T cells specifically recogn

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