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Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

  • Author(s): Shah, Neil Pravin
  • Ciceri, P
  • Müller, S
  • O'Mahony, A
  • Fedorov, O
  • Filippakopoulos, P
  • Hunt, JP
  • Lasater, EA
  • Pallares, G
  • Picaud, S
  • Wells, C
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3998711?pdf=render
No data is associated with this publication.
Abstract

Concomitant inhibition of multiple cancer-driving kinases is an established strategy to improve the durability of clinical responses to targeted therapies. The difficulty of discovering kinase inhibitors with an appropriate multitarget profile has, however

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