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Dicarboxylic acids as pH sensors for hyperpolarized C-13 magnetic resonance spectroscopic imaging

  • Author(s): Korenchan, DE
  • Taglang, C
  • von Morze, C
  • Blecha, JE
  • Gordon, JW
  • Sriram, R
  • Larson, PEZ
  • Vigneron, DB
  • VanBrocklin, HF
  • Kurhanewicz, J
  • Wilson, DM
  • Flavell, RR
  • et al.
Abstract

Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.

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