Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
- Wen, Wanqing;
- Zheng, Wei;
- Okada, Yukinori;
- Takeuchi, Fumihiko;
- Tabara, Yasuharu;
- Hwang, Joo-Yeon;
- Dorajoo, Rajkumar;
- Li, Huaixing;
- Tsai, Fuu-Jen;
- Yang, Xiaobo;
- He, Jiang;
- Wu, Ying;
- He, Meian;
- Zhang, Yi;
- Liang, Jun;
- Guo, Xiuqing;
- Sheu, Wayne Huey-Herng;
- Delahanty, Ryan;
- Guo, Xingyi;
- Kubo, Michiaki;
- Yamamoto, Ken;
- Ohkubo, Takayoshi;
- Go, Min Jin;
- Liu, Jian Jun;
- Gan, Wei;
- Chen, Ching-Chu;
- Gao, Yong;
- Li, Shengxu;
- Lee, Nanette R;
- Wu, Chen;
- Zhou, Xueya;
- Song, Huaidong;
- Yao, Jie;
- Lee, I-Te;
- Long, Jirong;
- Tsunoda, Tatsuhiko;
- Akiyama, Koichi;
- Takashima, Naoyuki;
- Cho, Yoon Shin;
- Ong, Rick TH;
- Lu, Ling;
- Chen, Chien-Hsiun;
- Tan, Aihua;
- Rice, Treva K;
- Adair, Linda S;
- Gui, Lixuan;
- Allison, Matthew;
- Lee, Wen-Jane;
- Cai, Qiuyin;
- Isomura, Minoru;
- Umemura, Satoshi;
- Kim, Young Jin;
- Seielstad, Mark;
- Hixson, James;
- Xiang, Yong-Bing;
- Isono, Masato;
- Kim, Bong-Jo;
- Sim, Xueling;
- Lu, Wei;
- Nabika, Toru;
- Lee, Juyoung;
- Lim, Wei-Yen;
- Gao, Yu-Tang;
- Takayanagi, Ryoichi;
- Kang, Dae-Hee;
- Wong, Tien Yin;
- Hsiung, Chao Agnes;
- Wu, I-Chien;
- Juang, Jyh-Ming Jimmy;
- Shi, Jiajun;
- Choi, Bo Youl;
- Aung, Tin;
- Hu, Frank;
- Kim, Mi Kyung;
- Lim, Wei Yen;
- Wang, Tzung-Dao;
- Shin, Min-Ho;
- Lee, Jeannette;
- Ji, Bu-Tian;
- Lee, Young-Hoon;
- Young, Terri L;
- Shin, Dong Hoon;
- Chun, Byung-Yeol;
- Cho, Myeong-Chan;
- Han, Bok-Ghee;
- Hwu, Chii-Min;
- Assimes, Themistocles L;
- Absher, Devin;
- Yan, Xiaofei;
- Kim, Eric;
- Kuo, Jane Z;
- Kwon, Soonil;
- Taylor, Kent D;
- Chen, Yii-Der I;
- Rotter, Jerome I;
- Qi, Lu;
- Zhu, Dingliang;
- Wu, Tangchun;
- Mohlke, Karen L;
- Gu, Dongfeng;
- Mo, Zengnan;
- Wu, Jer-Yuarn;
- Lin, Xu;
- Miki, Tetsuro;
- Tai, E Shyong;
- Lee, Jong-Young;
- Kato, Norihiro;
- Shu, Xiao-Ou;
- Tanaka, Toshihiro
- et al.
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168820/Abstract
Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.
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