Skip to main content
eScholarship
Open Access Publications from the University of California

Imaging in turbid media: a transmission detector gives 2-3 order of magnitude enhanced sensitivity compared to epi-detection schemes.

  • Author(s): Dvornikov, Alexander
  • Gratton, Enrico
  • et al.
Abstract

Imaging depth in turbid media by two-photon fluorescence microscopy depends on the ability of the optical system to detect weak fluorescence signals. We have shown that use of a wide area detector in transmission geometry allows increasing imaging depth in turbid media due to efficient photon collection. Compared to the conventional epi-detection scheme used in most commercial microscopes, the transmission detector was found to be 2-3 orders of magnitude more sensitive when used for in depth imaging in scattering samples simulating brain optical properties.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View