Lawrence Berkeley National Laboratory

The tumor-involved regions of head and neck cancer (HNC) have complex anatomical structures and vital physiological roles. As a consequence, there is a need for high sensitivity and high spatial resolution dedicated HNC PET scanner. The purpose of this study is to evaluate and optimize system design that includes detecting materials and geometries. For the detecting material, two scanners with the same two-panel geometry based on CZT and LYSO were evaluated. For the system geometry, four CZT scanners with two-panel, lengthened two-panel, four-panel, and full-ring geometries were evaluated. A cylinder phantom with sphere lesions and an XCAT phantom in the head and neck region were simulated. The results showed that the sensitivity of the 40-mm thickness CZT system and the 20-mm thickness LYSO system were comparable. However, the multiple interaction photon events recovery accuracy of the CZT system was about 20% higher. The in-panel and orthogonal-panel spatial resolutions of CZT are 0.58 and 0.74 mm, while those of LYSO are 0.70 and 1.40 mm. For system geometry, the four-panel and full-ring scanners have a higher contrast recovery coefficient (CRC) and contrast-to-noise ratio (CNR) than the two-panel and lengthened two-panel scanners. However, a 5-mm lesion in the XCAT phantom was visualized within 6 min in the two-panel system.