UCLA

Surface-enhanced Raman spectroscopy (SERS) is a surface-sensitive technique that can enhance the intensity of Raman signal by several orders of magnitude, enabling even the detection of single molecule. This work presents the experimental and theoretical studies of an optical fiber probe with nano-structured end-facet for bio-sensing applications via SERS. The factors affecting the intensity of Raman signal passing through the fiber probe are investigated. These factors include the numerical aperture of the objective lens, the slit width of the spectrometer, the fiber length, and the size of SERS nano-array. The Raman signal loss through fiber compared with optical microscope-based free-space Raman detection is estimated. To further enhance the SERS enhancement factor, a hybrid graphene/Au nano-triangle structure is transferred on the end-facet of the fiber probe to enable SERS. Superimposing graphene layer on Au nano-structure is found to be superior over bare Au nano-structure in terms of the detection sensitivity. Copyright © 2016 John Wiley & Sons, Ltd.