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Molecular definition of the identity and activation of natural killer cells

  • Author(s): Bezman, NA
  • Kim, CC
  • Sun, JC
  • Min-Oo, G
  • Hendricks, DW
  • Kamimura, Y
  • Best, JA
  • Goldrath, AW
  • Lanier, LL
  • Gautier, EL
  • Jakubzick, C
  • Randolph, GJ
  • Best, AJ
  • Knell, J
  • Miller, J
  • Brown, B
  • Merad, M
  • Jojic, V
  • Koller, D
  • Cohen, N
  • Brennan, P
  • Brenner, M
  • Shay, T
  • Regev, A
  • Fletcher, A
  • Elpek, K
  • Bellemare-Pelletier, A
  • Malhotra, D
  • Turley, S
  • Jianu, R
  • Laidlaw, D
  • Collins, JJ
  • Narayan, K
  • Sylvia, K
  • Kang, J
  • Gazit, R
  • Rossi, DJ
  • Kim, F
  • Rao, TN
  • Wagers, A
  • Shinton, SA
  • Hardy, RR
  • Monach, P
  • Kim, CC
  • Heng, T
  • Kreslavsky, T
  • Painter, M
  • Ericson, J
  • Davis, S
  • Mathis, D
  • Benoist, C
  • et al.

Published Web Location

https://doi.org/10.1038/ni.2395
Abstract

Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cells are known to share expression of a few genes with cytotoxic CD8 + T cells, our transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many encoding molecules with unknown functions. Resting NK cells demonstrate a 'preprimed' state compared with naive T cells, which allows NK cells to respond more rapidly to viral infection. Collectively, our data provide a global context for known and previously unknown molecular aspects of NK cell identity and function by delineating the genome-wide repertoire of gene expression of NK cells in various states. © 2012 Nature America, Inc. All rights reserved.

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