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Uterine smooth muscle tumors with features suggesting fumarate hydratase aberration: detailed morphologic analysis and correlation with S-(2-succino)-cysteine immunohistochemistry.
- Author(s): Garg, Karuna
- Reyes, C
- Karamurzin, Y
- Frizzell, N
- Nonaka, D
- Chen, Y-B
- Soslow, RA
- et al.
Published Web Location
http://europepmc.org/articles/PMC4048336?pdf=renderNo data is associated with this publication.
Abstract
Rare, sporadic uterine leiomyomas arise in the setting of severe metabolic aberration due to a somatic fumarate hydratase mutation. Germline mutations account for the hereditary leiomyomatosis and renal cell carcinoma syndrome, which predisposes for cutane
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