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Down syndrome: Distribution of brain amyloid in mild cognitive impairment.

  • Author(s): Keator, David B;
  • Phelan, Michael J;
  • Taylor, Lisa;
  • Doran, Eric;
  • Krinsky-McHale, Sharon;
  • Price, Julie;
  • Ballard, Erin E;
  • Kreisl, William C;
  • Hom, Christy;
  • Nguyen, Dana;
  • Pulsifer, Margaret;
  • Lai, Florence;
  • Rosas, Diana H;
  • Brickman, Adam M;
  • Schupf, Nicole;
  • Yassa, Michael A;
  • Silverman, Wayne;
  • Lott, Ira T
  • et al.
Abstract

Introduction

Down syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment in DS (MCI-DS) and test these hypotheses using cross-sectional and longitudinal data.

Methods

18F-AV-45 (florbetapir) positron emission tomography (PET) data were collected to analyze amyloid burden in 58 participants clinically classified as cognitively stable (CS) or MCI-DS and 12 longitudinal CS participants.

Results

The study confirmed our hypotheses of increased amyloid in inferior parietal, lateral occipital, and superior frontal regions as the main effects differentiating MCI-DS from the CS groups. The largest annualized amyloid increases in longitudinal CS data were in the rostral middle frontal, superior frontal, superior/middle temporal, and posterior cingulate cortices.

Discussion

This study helps us to understand amyloid in the MCI-DS transitional state between cognitively stable aging and frank dementia in DS. The spatial distribution of Aβ may be a reliable indicator of MCI-DS in DS.

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