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A carbonate-forming Baeyer-Villiger monooxygenase.

  • Author(s): Hu, Youcai
  • Dietrich, David
  • Xu, Wei
  • Patel, Ashay
  • Thuss, Justin AJ
  • Wang, Jingjing
  • Yin, Wen-Bing
  • Qiao, Kangjian
  • Houk, KN
  • Vederas, John C
  • Tang, Yi
  • et al.

Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase, CcsB, which catalyzes the formation of an in-line carbonate in the macrocyclic portion of cytochalasin E. This study expands the repertoire of activities of FMOs and provides a possible synthetic strategy for transformation of ketones into carbonates.

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