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A carbonate-forming Baeyer-Villiger monooxygenase.

  • Author(s): Hu, Youcai;
  • Dietrich, David;
  • Xu, Wei;
  • Patel, Ashay;
  • Thuss, Justin AJ;
  • Wang, Jingjing;
  • Yin, Wen-Bing;
  • Qiao, Kangjian;
  • Houk, KN;
  • Vederas, John C;
  • Tang, Yi
  • et al.
Abstract

Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase, CcsB, which catalyzes the formation of an in-line carbonate in the macrocyclic portion of cytochalasin E. This study expands the repertoire of activities of FMOs and provides a possible synthetic strategy for transformation of ketones into carbonates.

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