Skip to main content
Download PDF
- Main
A carbonate-forming Baeyer-Villiger monooxygenase.
- Author(s): Hu, Youcai
- Dietrich, David
- Xu, Wei
- Patel, Ashay
- Thuss, Justin AJ
- Wang, Jingjing
- Yin, Wen-Bing
- Qiao, Kangjian
- Houk, KN
- Vederas, John C
- Tang, Yi
- et al.
Published Web Location
https://doi.org/10.1038/nchembio.1527Abstract
Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase, CcsB, which catalyzes the formation of an in-line carbonate in the macrocyclic portion of cytochalasin E. This study expands the repertoire of activities of FMOs and provides a possible synthetic strategy for transformation of ketones into carbonates.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.