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Performance of an influenza rapid test in children in a primary healthcare setting in Nicaragua.

  • Author(s): Gordon, Aubree
  • Videa, Elsa
  • Saborio, Saira
  • López, Roger
  • Kuan, Guillermina
  • Reingold, Arthur
  • Balmaseda, Angel
  • Harris, Eva
  • et al.
Abstract

Background

Influenza is major public health threat worldwide, yet the diagnostic accuracy of rapid tests in developing country settings is not well described.

Methodology/principal findings

To investigate the diagnostic accuracy of the QuickVue Influenza A+B test in a primary care setting in a developing country, we performed a prospective study of diagnostic accuracy of the QuickVue Influenza A+B test in comparison to reverse transcriptase-polymerase chain reaction (RT-PCR) in a primary healthcare setting in children aged 2 to 12 years in Managua, Nicaragua. The sensitivity and specificity of the QuickVue test compared to RT-PCR were 68.5% (95% CI 63.4, 73.3) and 98.1% (95% CI 96.9, 98.9), respectively, for children with a fever or history of a fever and cough and/or sore throat. Test performance was found to be lower on the first day that symptoms developed in comparison to test performance on days two or three of illness.

Conclusions/significance

Our study found that the QuickVue Influenza A+B test performed as well in a developing country primary healthcare facility setting as in developed country settings.

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