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Report of the Jumpstarting Brain Tumor Drug Development Coalition and FDA clinical trials neuroimaging endpoint workshop (January 30, 2014, Bethesda MD).

  • Author(s): Wen, Patrick Y;
  • Cloughesy, Timothy F;
  • Ellingson, Benjamin M;
  • Reardon, David A;
  • Fine, Howard A;
  • Abrey, Lauren;
  • Ballman, Karla;
  • Bendszuz, Martin;
  • Buckner, Jan;
  • Chang, Susan M;
  • Prados, Michael D;
  • Pope, Whitney B;
  • Gregory Sorensen, Alma;
  • van den Bent, Martin;
  • Yung, Wai-Kwan Alfred
  • et al.

On January 30, 2014, a workshop was held on neuroimaging endpoints in high-grade glioma. This workshop was sponsored by the Jumpstarting Brain Tumor Drug Development Coalition, consisting of the National Brain Tumor Society, the Society for Neuro-Oncology, Accelerate Brain Cancer Cure, and the Musella Foundation for Research and Information, and conducted in collaboration with the Food and Drug Administration. The workshop included neuro-oncologists, neuroradiologists, radiation oncologists, neurosurgeons, biostatisticians, patient advocates, and representatives from industry, clinical research organizations, and the National Cancer Institute. This report summarizes the presentations and discussions of that workshop and the proposals that emerged to improve the Response Assessment in Neuro-Oncology (RANO) criteria and standardize neuroimaging parameters.

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