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Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study)

  • Author(s): Sartelli, Massimo
  • Catena, Fausto
  • Ansaloni, Luca
  • Moore, Ernest
  • Malangoni, Mark
  • Velmahos, George
  • Coimbra, Raul
  • Koike, Kaoru
  • Leppaniemi, Ari
  • Biffl, Walter
  • Balogh, Zsolt
  • Bendinelli, Cino
  • Gupta, Sanjay
  • Kluger, Yoram
  • Agresta, Ferdinando
  • di Saverio, Salomone
  • Tugnoli, Gregorio
  • Jovine, Elio
  • Ordonez, Carlos
  • Gomes, Carlos Augusto
  • Junior, Gerson Alves Pereira
  • Yuan, Kuo-Ching
  • Bala, Miklosh
  • Peev, Miroslav P
  • Cui, Yunfeng
  • Marwah, Sanjay
  • Zachariah, Sanoop
  • Sakakushev, Boris
  • Kong, Victor
  • Ahmed, Adamu
  • Abbas, Ashraf
  • Gonsaga, Ricardo Alessandro Teixeira
  • Guercioni, Gianluca
  • Vettoretto, Nereo
  • Poiasina, Elia
  • Ben-Ishay, Offir
  • Díaz-Nieto, Rafael
  • Massalou, Damien
  • Skrovina, Matej
  • Gerych, Ihor
  • Augustin, Goran
  • Kenig, Jakub
  • Khokha, Vladimir
  • Tranà, Cristian
  • Kok, Kenneth Yuh Yen
  • Mefire, Alain Chichom
  • Lee, Jae Gil
  • Hong, Suk-Kyung
  • Lohse, Helmut Alfredo Segovia
  • Ghnnam, Wagih
  • Verni, Alfredo
  • Lohsiriwat, Varut
  • Siribumrungwong, Boonying
  • Tavares, Alberto
  • Baiocchi, Gianluca
  • Das, Koray
  • Jarry, Julien
  • Zida, Maurice
  • Sato, Norio
  • Murata, Kiyoshi
  • Shoko, Tomohisa
  • Irahara, Takayuki
  • Hamedelneel, Ahmed O
  • Naidoo, Noel
  • Adesunkanmi, Abdul Rashid Kayode
  • Kobe, Yoshiro
  • Attri, AK
  • Sharma, Rajeev
  • Coccolini, Federico
  • El Zalabany, Tamer
  • Khalifa, Khalid Al
  • Sanjuan, Juan
  • Barnabé, Rita
  • Ishii, Wataru
  • et al.

Abstract Despite advances in diagnosis, surgery, and antimicrobial therapy, mortality rates associated with complicated intra-abdominal infections remain exceedingly high. The World Society of Emergency Surgery (WSES) has designed the CIAOW study in order to describe the clinical, microbiological, and management-related profiles of both community- and healthcare-acquired complicated intra-abdominal infections in a worldwide context. The CIAOW study (Complicated Intra-Abdominal infection Observational Worldwide Study) is a multicenter observational study currently underway in 57 medical institutions worldwide. The study includes patients undergoing surgery or interventional drainage to address complicated intra-abdominal infections. This preliminary report includes all data from almost the first two months of the six-month study period. Patients who met inclusion criteria with either community-acquired or healthcare-associated complicated intra-abdominal infections (IAIs) were included in the study. 702 patients with a mean age of 49.2 years (range 18–98) were enrolled in the study. 272 patients (38.7%) were women and 430 (62.3%) were men. Among these patients, 615 (87.6%) were affected by community-acquired IAIs while the remaining 87 (12.4%) suffered from healthcare-associated infections. Generalized peritonitis was observed in 304 patients (43.3%), whereas localized peritonitis or abscesses was registered in 398 (57.7%) patients. The overall mortality rate was 10.1% (71/702). The final results of the CIAOW Study will be published following the conclusion of the study period in March 2013.

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