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Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes theintegrated stress response

  • Author(s): Renslo, Adam
  • Walter, Peter
  • Sidrauski, C
  • Tsai, JC
  • Kampmann, M
  • Hearn, BR
  • Vedantham, P
  • Jaishankar, P
  • Sokabe, M
  • Mendez, AS
  • Newton, BW
  • Tang, EL
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4426669?pdf=render
No data is associated with this publication.
Abstract

© 2015, eLife. All rights reserve.The general translation initiation factor eIF2 is a major translational control point. Multiple signaling pathways in the integrated stress response phosphorylate eIF2 serine-51, inhibiting nucleotide exchange by eIF2B. IS

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