Skip to main content
eScholarship
Open Access Publications from the University of California

Allostery in Its Many Disguises: From Theory to Applications.

  • Author(s): Wodak, Shoshana J
  • Paci, Emanuele
  • Dokholyan, Nikolay V
  • Berezovsky, Igor N
  • Horovitz, Amnon
  • Li, Jing
  • Hilser, Vincent J
  • Bahar, Ivet
  • Karanicolas, John
  • Stock, Gerhard
  • Hamm, Peter
  • Stote, Roland H
  • Eberhardt, Jerome
  • Chebaro, Yassmine
  • Dejaegere, Annick
  • Cecchini, Marco
  • Changeux, Jean-Pierre
  • Bolhuis, Peter G
  • Vreede, Jocelyne
  • Faccioli, Pietro
  • Orioli, Simone
  • Ravasio, Riccardo
  • Yan, Le
  • Brito, Carolina
  • Wyart, Matthieu
  • Gkeka, Paraskevi
  • Rivalta, Ivan
  • Palermo, Giulia
  • McCammon, J Andrew
  • Panecka-Hofman, Joanna
  • Wade, Rebecca C
  • Di Pizio, Antonella
  • Niv, Masha Y
  • Nussinov, Ruth
  • Tsai, Chung-Jung
  • Jang, Hyunbum
  • Padhorny, Dzmitry
  • Kozakov, Dima
  • McLeish, Tom
  • et al.
Abstract

Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, and metabolism. Allostery is rooted in the fundamental physical properties of macromolecular systems, but its underlying mechanisms are still poorly understood. A collection of contributions to a recent interdisciplinary CECAM (Center Européen de Calcul Atomique et Moléculaire) workshop is used here to provide an overview of the progress and remaining limitations in the understanding of the mechanistic foundations of allostery gained from computational and experimental analyses of real protein systems and model systems. The main conceptual frameworks instrumental in driving the field are discussed. We illustrate the role of these frameworks in illuminating molecular mechanisms and explaining cellular processes, and describe some of their promising practical applications in engineering molecular sensors and informing drug design efforts.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View