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Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum.

  • Author(s): Torres-Mendoza, Daniel
  • Coronado, Lorena M
  • Pineda, Laura M
  • Guzmán, Héctor M
  • Dorrestein, Pieter C
  • Spadafora, Carmenza
  • Gutiérrez, Marcelino
  • et al.
Abstract

Chemical examination of the octocoral-associated Bacillus species (sp.) DT001 led to the isolation of pumilacidins A (1) and C (2). We investigated the effect of these compounds on the viability of Plasmodium falciparum and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca2+.

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