Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum.
- Author(s): Torres-Mendoza, Daniel
- Coronado, Lorena M
- Pineda, Laura M
- Guzmán, Héctor M
- Dorrestein, Pieter C
- Spadafora, Carmenza
- Gutiérrez, Marcelino
- et al.
Published Web Locationhttps://doi.org/10.3390/molecules23092179
Chemical examination of the octocoral-associated Bacillus species (sp.) DT001 led to the isolation of pumilacidins A (1) and C (2). We investigated the effect of these compounds on the viability of Plasmodium falciparum and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca2+.