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Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes
- Romanoski, Casey E;
- Qi, Xinshuai;
- Sangam, Shreya;
- Vanderpool, Rebecca R;
- Stearman, Robert S;
- Conklin, Austin;
- Gonzalez‐Garay, Manuel;
- Rischard, Franz;
- Ayon, Ramon J;
- Wang, Jian;
- Simonson, Tatum;
- Babicheva, Aleksandra;
- Shi, Yinan;
- Tang, Haiyang;
- Makino, Ayako;
- Kanthi, Yogendra;
- Geraci, Mark W;
- Garcia, Joe GN;
- Yuan, Jason X‐J;
- Desai, Ankit A
- et al.
Published Web Location
https://doi.org/10.1177/2045894020968531Abstract
Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.
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