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Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes.

  • Author(s): Romanoski, Casey E;
  • Qi, Xinshuai;
  • Sangam, Shreya;
  • Vanderpool, Rebecca R;
  • Stearman, Robert S;
  • Conklin, Austin;
  • Gonzalez-Garay, Manuel;
  • Rischard, Franz;
  • Ayon, Ramon J;
  • Wang, Jian;
  • Simonson, Tatum;
  • Babicheva, Aleksandra;
  • Shi, Yinan;
  • Tang, Haiyang;
  • Makino, Ayako;
  • Kanthi, Yogendra;
  • Geraci, Mark W;
  • Garcia, Joe GN;
  • Yuan, Jason X-J;
  • Desai, Ankit A
  • et al.
Abstract

Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.

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