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Open Access Publications from the University of California

Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement.

  • Author(s): Kheradvar, Arash
  • Groves, Elliott M
  • Simmons, Craig A
  • Griffith, Boyce
  • Alavi, S Hamed
  • Tranquillo, Robert
  • Dasi, Lakshmi P
  • Falahatpisheh, Ahmad
  • Grande-Allen, K Jane
  • Goergen, Craig J
  • Mofrad, Mohammad RK
  • Baaijens, Frank
  • Canic, Suncica
  • Little, Stephen H
  • et al.

In this portion of an extensive review of heart valve engineering, we focus on the current and emerging technologies and techniques to repair or replace the mitral valve. We begin with a discussion of the currently available mechanical and bioprosthetic mitral valves followed by the rationale and limitations of current surgical mitral annuloplasty methods; a discussion of the technique of neo-chordae fabrication and implantation; a review the procedures and clinical results for catheter-based mitral leaflet repair; a highlight of the motivation for and limitations of catheter-based annular reduction therapies; and introduce the early generation devices for catheter-based mitral valve replacement.

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