Skip to main content
eScholarship
Open Access Publications from the University of California

Self-organization of protrusions and polarity during eukaryotic chemotaxis.

  • Author(s): Graziano, Brian R
  • Weiner, Orion D
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177965/
No data is associated with this publication.
Abstract

Many eukaryotic cells regulate their polarity and motility in response to external chemical cues. While we know many of the linear connections that link receptors with downstream actin polymerization events, we have a much murkier understanding of the higher order positive and negative feedback loops that organize these processes in space and time. Importantly, physical forces and actin polymerization events do not simply act downstream of chemotactic inputs but are rather involved in a web of reciprocal interactions with signaling components to generate self-organizing pseudopods and cell polarity. Here we focus on recent progress and open questions in the field, including the basic unit of actin organization, how cells regulate the number and speed of protrusions, and 2D versus 3D migration.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item