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Open Access Publications from the University of California

Assembly of the Transmembrane Domain of E. coli PhoQ Histidine Kinase: Implications for Signal Transduction from Molecular Simulations

  • Author(s): Degrado, William
  • Lemmin, T
  • Soto, CS
  • Clinthorne, G
  • DeGrado, WF
  • Dal, M
  • et al.

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The PhoQP two-component system is a signaling complex essential for bacterial virulence and cationic antimicrobial peptide resistance. PhoQ is the histidine kinase chemoreceptor of this tandem machine and assembles in a homodimer conformation spanning the

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